|Application ||WB, E|
|Calculated MW||44289 Da|
|Antigen Region||330-356 aa|
|Other Names||P2X purinoceptor 3, P2X3, ATP receptor, Purinergic receptor, P2RX3|
|Target/Specificity||This P2RX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-356 amino acids from the C-terminal region of human P2RX3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2RX3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)
Beneng, K., et al. Int J Oral Maxillofac Surg 39(8):815-819(2010)
Nair, A., et al. Cell. Mol. Neurobiol. 30(4):505-509(2010)
Jacques-Silva, M.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(14):6465-6470(2010)
Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :
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