|Application ||WB, E|
|Calculated MW||45016 Da|
|Antigen Region||23-49 aa|
|Other Names||Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline- and glutamine-rich protein, PQ-rich protein, PQR protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein, PHLDA1, PHRIP, TDAG51|
|Target/Specificity||This PHLDA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-49 amino acids from the N-terminal region of human PHLDA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHLDA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles|
|Tissue Location||Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Marchiori, A.C., et al. Braz. J. Med. Biol. Res. 41(7):579-582(2008)
Nagai, M.A., et al. Breast Cancer Res. Treat. 106(1):49-56(2007)
Xi, Z.Q., et al. Neurosci. Lett. 425(1):53-58(2007)
Meier-Noorden, M., et al. Gene 338(2):197-207(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.