|Application ||WB, E|
|Calculated MW||105417 Da|
|Antigen Region||600-626 aa|
|Other Names||Signal transducer and activator of transcription 2, Stat2|
|Target/Specificity||This Mouse Stat2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 600-626 amino acids from the Central region of mouse Stat2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Stat2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.|
|Tissue Location||Found in the brain, lung, heart, spleen, liver, kidney, muscle and the testis|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element. This multiprotein transcription factor is termed ISGF3.
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