|Application ||WB, E|
|Other Accession||Q9Y6F7, NP_001003894.1|
|Calculated MW||60473 Da|
|Antigen Region||1-30 aa|
|Other Names||Testis-specific chromodomain protein Y 1, CDY1, CDY1A|
|Target/Specificity||This CDY1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDY1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDY1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has histone acetyltransferase activity, with a preference for histone H4.|
|Tissue Location||Testis-specific. Detected in spermatids (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.
Kleiman, S.E., et al. Hum. Genet. 113(6):486-492(2003)
Dorus, S., et al. Hum. Mol. Genet. 12(14):1643-1650(2003)
Skaletsky, H., et al. Nature 423(6942):825-837(2003)
Lahn, B.T., et al. Proc. Natl. Acad. Sci. U.S.A. 99(13):8707-8712(2002)
Ferlin, A., et al. J. Endocrinol. Invest. 24 (2), RC4-RC6 (2001) :
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