|Application ||WB, E|
|Calculated MW||21849 Da|
|Antigen Region||109-137 aa|
|Other Names||C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL|
|Target/Specificity||This CLEC2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the Central region of human CLEC2D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC2D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLAX, LLT1, OCIL|
|Function||Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cell surface Isoform 4: Endoplasmic reticulum.|
|Tissue Location||Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
Germain, C., et al. J. Biol. Chem. (2010) In press :
Bambard, N.D., et al. Scand. J. Immunol. 71(3):210-219(2010)
Skinningsrud, B., et al. J. Clin. Endocrinol. Metab. 93(9):3310-3317(2008)
Rosen, D.B., et al. J. Immunol. 180(10):6508-6517(2008)
Pineda, B., et al. Calcif. Tissue Int. 82(5):348-353(2008)
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