|Application ||WB, E|
|Other Accession||Q60HE7, NP_055981.1|
|Calculated MW||41141 Da|
|Antigen Region||337-366 aa|
|Other Names||Membrane protein MLC1, MLC1, KIAA0027, WKL1|
|Target/Specificity||This MLC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the C-terminal region of human MLC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MLC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum|
|Tissue Location||Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
Yis, U., et al. Turk. J. Pediatr. 52(2):179-183(2010)
Lanciotti, A., et al. Neurobiol. Dis. 37(3):581-595(2010)
Shukla, P., et al. Prenat. Diagn. 28(4):357-359(2008)
Ambrosini, E., et al. Mol. Cell. Neurosci. 37(3):480-493(2008)
Selch, S., et al. Biol. Psychiatry 61(10):1211-1214(2007)
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