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ST6GALNAC4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H4F1 |
| Other Accession | Q9R2B6, NP_778204.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34201 Da |
| Antigen Region | 181-209 aa |
| Gene ID | 27090 |
|---|---|
| Other Names | Alpha-N-acetyl-neuraminyl-2, 3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2, 6-sialyltransferase, NeuAc-alpha-2, 3-Gal-beta-1, 3-GalNAc-alpha-2, 6-sialyltransferase, ST6GalNAc IV, ST6GalNAcIV, Sialyltransferase 3C, SIAT3-C, Sialyltransferase 7D, SIAT7-D, ST6GALNAC4, SIAT3C, SIAT7D |
| Target/Specificity | This ST6GALNAC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human ST6GALNAC4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ST6GALNAC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST6GALNAC4 |
|---|---|
| Synonyms | SIAT3C, SIAT7D |
| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. Prefers O-glycans to glycoproteins or glycolipids. |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.
References
Yoshino, H., et al. Brain Res. 1227, 216-220 (2008) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Kang, N.Y., et al. Mol. Cells 18(2):157-162(2004)
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