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CALHM3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86XJ0 |
| Other Accession | NP_001123214.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38496 Da |
| Antigen Region | 68-97 aa |
| Gene ID | 119395 |
|---|---|
| Other Names | Calcium homeostasis modulator protein 3, Protein FAM26A, CALHM3, FAM26A |
| Target/Specificity | This CALHM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from the N-terminal region of human CALHM3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CALHM3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALHM3 (HGNC:23458) |
|---|---|
| Synonyms | FAM26A |
| Function | Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. |
| Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:J3QMI4}; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in circumvallate taste bud cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of CALHM3 remains unknown. There are two different isoforms generated by alternative splicing.
References
Shibata, N., et al. J. Alzheimers Dis. 20(2):417-421(2010)
Dreses-Werringloer, U., et al. Cell 133(7):1149-1161(2008)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
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