|Application ||WB, E|
|Other Accession||O97490, Q9R0R1, NP_005920.2|
|Calculated MW||80215 Da|
|Antigen Region||627-655 aa|
|Other Names||Melanotransferrin, Melanoma-associated antigen p97, CD228, MFI2, MAP97|
|Target/Specificity||This MFI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 627-655 amino acids from the C-terminal region of human MFI2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MFI2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.|
|Cellular Location||Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor|
|Tissue Location||Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq].
Wang, M., et al. J. Biol. Chem. 284(48):33377-33383(2009)
Farnaud, S., et al. Int. J. Biochem. Cell Biol. 40(12):2739-2745(2008)
Suryo Rahmanto, Y., et al. Carcinogenesis 28(10):2172-2183(2007)
Suryo Rahmanto, Y., et al. Oncogene 26(42):6113-6124(2007)
Michaud-Levesque, J., et al. Biol. Chem. 388(7):747-754(2007)
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