Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
MFI2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P08582 |
| Other Accession | O97490, Q9R0R1, NP_005920.2 |
| Reactivity | Human |
| Predicted | Mouse, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80215 Da |
| Antigen Region | 627-655 aa |
| Gene ID | 4241 |
|---|---|
| Other Names | Melanotransferrin, Melanoma-associated antigen p97, CD228, MFI2, MAP97 |
| Target/Specificity | This MFI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 627-655 amino acids from the C-terminal region of human MFI2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MFI2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MELTF (HGNC:7037) |
|---|---|
| Synonyms | MAP97, MFI2 |
| Function | Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. |
| Cellular Location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI- anchor |
| Tissue Location | Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq].
References
Wang, M., et al. J. Biol. Chem. 284(48):33377-33383(2009)
Farnaud, S., et al. Int. J. Biochem. Cell Biol. 40(12):2739-2745(2008)
Suryo Rahmanto, Y., et al. Carcinogenesis 28(10):2172-2183(2007)
Suryo Rahmanto, Y., et al. Oncogene 26(42):6113-6124(2007)
Michaud-Levesque, J., et al. Biol. Chem. 388(7):747-754(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
