|Application ||WB, E|
|Other Accession||Q9Z2M7, Q60HD6, Q3SZJ9, NP_000294.1|
|Predicted||Mouse, Monkey, Bovine|
|Calculated MW||28082 Da|
|Antigen Region||198-226 aa|
|Other Names||Phosphomannomutase 2, PMM 2, PMM2|
|Target/Specificity||This PMM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the C-terminal region of human PMM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PMM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq].
Vega, A.I., et al. Hum. Mutat. 30(5):795-803(2009)
Coman, D., et al. Am. J. Med. Genet. A 146(3):389-392(2008)
Vermeer, S., et al. J. Neurol. 254(10):1356-1358(2007)
Coman, D., et al. J Clin Neurosci 14(7):668-672(2007)
Schollen, E., et al. Mol. Genet. Metab. 90(4):408-413(2007)
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