|Application ||WB, E|
|Calculated MW||53525 Da|
|Antigen Region||23-49 aa|
|Other Names||Polyadenylate-binding protein-interacting protein 1, PABP-interacting protein 1, PAIP-1, Poly(A)-binding protein-interacting protein 1, PAIP1|
|Target/Specificity||This PAIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-49 amino acids from the N-terminal region of human PAIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Kanaan, A.S., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 10), 1060-1064 (2009) :
Martineau, Y., et al. Mol. Cell. Biol. 28(21):6658-6667(2008)
Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :
Roy, G., et al. Mol. Cell. Biol. 22(11):3769-3782(2002)
Deo, R.C., et al. Proc. Natl. Acad. Sci. U.S.A. 98(8):4414-4419(2001)
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