|Application ||WB, E|
|Other Accession||Q2HJI8, NP_057614.1|
|Calculated MW||23584 Da|
|Antigen Region||172-198 aa|
|Other Names||Ras-related protein Rab-8B, RAB8B|
|Target/Specificity||This RAB8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-198 amino acids from the C-terminal region of human RAB8B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB8B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).
Heidrych, P., et al. Hum. Mol. Genet. 17(23):3814-3821(2008)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lau, A.S., et al. Endocrinology 144(4):1549-1563(2003)
Hattula, K., et al. Mol. Biol. Cell 13(9):3268-3280(2002)
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