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SCUBE3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SCUBE3 Antibody (Center) AP19055C
    SCUBE3 Antibody (Center) (Cat. #AP19055c) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the SCUBE3 antibody detected the SCUBE3 protein (arrow).
  • WB - SCUBE3 Antibody (Center) AP19055C
    SCUBE3 Antibody (Center) (Cat. #AP19055c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the SCUBE3 antibody detected the SCUBE3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IX30
Other Accession NP_689966.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 109282 Da
Antigen Region 480-509 aa
Additional Information
Gene ID 222663
Other Names Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)
Target/Specificity This SCUBE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the Central region of human SCUBE3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSCUBE3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCUBE3 (HGNC:13655)
Function Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Cellular Location Secreted. Cell surface
Tissue Location Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.
Research Areas
Citations (0)

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SCUBE3 contains one CUB domain and 9 EGF-like domains. It is highly expressed in primary osteoblasts and the long bones (humerus and femur) and expression is low or absent in non-bone tissues. It may play an important role in bone cell biology.


Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) : Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008) Wu, B.T., et al. J. Biol. Chem. 279(36):37485-37490(2004) Mungall, A.J., et al. Nature 425(6960):805-811(2003) Yang, R.B., et al. J. Biol. Chem. 277(48):46364-46373(2002)

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$ 295.00
$ 99.00
Cat# AP19055C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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