|Application ||WB, E|
|Other Accession||P70470, O77821, P97823, NP_006321.1|
|Predicted||Mouse, Rabbit, Rat|
|Calculated MW||24670 Da|
|Antigen Region||65-94 aa|
|Other Names||Acyl-protein thioesterase 1, APT-1, hAPT1, 312-, Lysophospholipase 1, Lysophospholipase I, LPL-I, LysoPLA I, LYPLA1, APT1, LPL1|
|Target/Specificity||This LYPLA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-94 amino acids from the Central region of human LYPLA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LYPLA1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.|
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Provided below are standard protocols that you may find useful for product applications.
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.
Satou, M., et al. Endocrinology 151(10):4765-4775(2010)
Dekker, F.J., et al. Nat. Chem. Biol. 6(6):449-456(2010)
Hirano, T., et al. Biochim. Biophys. Acta 1791(8):797-805(2009)
Siegel, G., et al. Nat. Cell Biol. 11(6):705-716(2009)
Devedjiev, Y., et al. Structure 8(11):1137-1146(2000)
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