|Application ||WB, E|
|Calculated MW||39646 Da|
|Antigen Region||74-104 aa|
|Other Names||Mitochondrial import inner membrane translocase subunit TIM50, TIMM50, TIM50|
|Target/Specificity||This TIMM50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-104 amino acids from the N-terminal region of human TIMM50.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMM50 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Xu, H., et al. BMC Cell Biol. 6 (1), 29 (2005) :
Guo, Y., et al. J. Biol. Chem. 279(23):24813-24825(2004)
Yuryev, A., et al. Genomics 81(2):112-125(2003)
Yamamoto, H., et al. Cell 111(4):519-528(2002)
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