|Application ||WB, E|
|Other Accession||Q8CG07, Q91XU0, NP_064520.2|
|Calculated MW||72133 Da|
|Antigen Region||1-30 aa|
|Other Names||ATPase WRNIP1, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876)|
|Target/Specificity||This WRNIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human WRNIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WRNIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.|
|Cellular Location||Nucleus. Note=Colocalizes with WRN in granular structures in the nucleus.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.
Kaur, S., et al. Cell Cycle 9(15):3106-3111(2010)
Yoshimura, A., et al. Genes Genet. Syst. 84(2):171-178(2009)
Crosetto, N., et al. J. Biol. Chem. 283(50):35173-35185(2008)
Mano, Y., et al. Cancer Sci. 98(12):1902-1913(2007)
Bish, R.A., et al. J. Biol. Chem. 282(32):23184-23193(2007)
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