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PRKCSH Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P14314 |
| Other Accession | Q28034, NP_002734.2 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59425 Da |
| Antigen Region | 6-35 aa |
| Gene ID | 5589 |
|---|---|
| Other Names | Glucosidase 2 subunit beta, 80K-H protein, Glucosidase II subunit beta, Protein kinase C substrate 601 kDa protein heavy chain, PKCSH, PRKCSH, G19P1 |
| Target/Specificity | This PRKCSH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human PRKCSH. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRKCSH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRKCSH {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:9411} |
|---|---|
| Function | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). |
| Cellular Location | Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138, ECO:0000305|PubMed:10929008} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER). This protein is an acidic phospho-protein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease (PCLD). Alternatively spliced transcript variants encoding distinct isoforms have been observed.
References
Hoverfelt, A., et al. Diabetologia 53(9):1903-1907(2010)
Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)
van Keimpema, L., et al. Liver Int. (2010) In press :
Yang, A.M., et al. Dig. Dis. Sci. 55(3):815-819(2010)
Gao, H., et al. Hum. Mol. Genet. 19(1):16-24(2010)
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