|Application ||WB, E|
|Calculated MW||48207 Da|
|Antigen Region||406-433 aa|
|Other Names||Transcobalamin-1, TC-1, Haptocorrin, HC, Protein R, Transcobalamin I, TC I, TCI, TCN1, TC1|
|Target/Specificity||This TCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-433 amino acids from the C-terminal region of human TCN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.|
|Tissue Location||Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Garrod, M.G., et al. Eur J Clin Nutr 64(5):503-509(2010)
Matteini, A.M., et al. J Nutr Health Aging 14(1):73-77(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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