|Application ||WB, E|
|Calculated MW||49347 Da|
|Antigen Region||390-418 aa|
|Other Names||Repulsive guidance molecule A, RGM domain family member A, RGMA, RGM|
|Target/Specificity||This RGMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human RGMA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGMA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants.
Nohra, R., et al. Genes Immun. 11(4):279-293(2010)
Severyn, C.J., et al. Biochem. J. 422(3):393-403(2009)
Li, V.S., et al. Gastroenterology 137(1):176-187(2009)
Endo, M., et al. J. Neurosci. 29(20):6649-6662(2009)
Hata, K., et al. J. Cell Biol. 184(5):737-750(2009)
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