|Application ||WB, E|
|Calculated MW||67814 Da|
|Antigen Region||77-103 aa|
|Other Names||TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L, PCAF-associated factor 65-alpha, PAF65-alpha, TAF6L, PAF65A|
|Target/Specificity||This TAF6L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-103 amino acids from the N-terminal region of human TAF6L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAF6L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation.
Clarke, D.L., et al. J. Immunol. 181(5):3503-3514(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
Pitkanen, J., et al. Biochem. Biophys. Res. Commun. 333(3):944-953(2005)
Cavusoglu, N., et al. Proteomics 3(2):217-223(2003)
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