|Application ||WB, E|
|Calculated MW||80778 Da|
|Antigen Region||686-715 aa|
|Other Names||Protein-glutamine gamma-glutamyltransferase 5, Transglutaminase X, TG(X), TGX, TGase X, Transglutaminase-5, TGase-5, TGM5, TGMX|
|Target/Specificity||This TGM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 686-715 amino acids from the C-terminal region of human TGM5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGM5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.|
|Cellular Location||Cytoplasm. Note=Associated with intermediate filaments|
|Tissue Location||Expressed in foreskin keratinocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.
Kiritsi, D., et al. J. Invest. Dermatol. 130(6):1741-1746(2010)
Kharfi, M., et al. J. Invest. Dermatol. 129(10):2512-2515(2009)
Broderick, P., et al. Cancer Res. 69(16):6633-6641(2009)
Pietroni, V., et al. J. Invest. Dermatol. 128(12):2760-2766(2008)
Cassidy, A.J., et al. Am. J. Hum. Genet. 77(6):909-917(2005)
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