|Application ||WB, E|
|Calculated MW||76993 Da|
|Antigen Region||352-380 aa|
|Other Names||Rhophilin-2, 76 kDa RhoB effector protein, GTP-Rho-binding protein 2, p76RBE, RHPN2|
|Target/Specificity||This RHPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from the Central region of human RHPN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RHPN2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq].
Abuli, A., et al. Gastroenterology 139(3):788-796(2010)
von Holst, S., et al. Br. J. Cancer 103(4):575-580(2010)
Kupfer, S.S., et al. Gastroenterology (2010) In press :
Xiong, F., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1855-1861(2010)
Hawken, S.J., et al. Hum. Genet. 128(1):89-101(2010)
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