|Application ||WB, E|
|Calculated MW||40748 Da|
|Antigen Region||218-244 aa|
|Other Names||Septin-12, SEPT12|
|Target/Specificity||This SEPT12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-244 amino acids from the Central region of human SEPT12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Septins, such as SEPT12, are conserved GTP-binding proteins that function as dynamic, regulatable scaffolds for the recruitment of other proteins. They are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeleton remodeling, as well as infection, neurodegeneration, and neoplasia (Hall et al., 2005 [PubMed 15915442]).
Lin, Y.H., et al. Am. J. Pathol. 174(5):1857-1868(2009)
Ding, X., et al. Mol. Cells 25(3):385-389(2008)
Ding, X., et al. J. Biochem. Mol. Biol. 40(6):973-978(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hall, P.A., et al. J. Pathol. 206(3):269-278(2005)
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