|Application ||WB, E|
|Calculated MW||87428 Da|
|Antigen Region||283-310 aa|
|Other Names||PAS domain-containing protein 1, Cancer/testis antigen 63, CT63, OX-TES-1, PASD1|
|Target/Specificity||This PASD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the Central region of human PASD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PASD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).|
|Cellular Location||Isoform 1: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).|
|Tissue Location||Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL- derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.
Ghafouri-Fard, S., et al. Br. J. Dermatol. 162(4):772-779(2010)
Ait-Tahar, K., et al. Br. J. Haematol. 146(4):396-407(2009)
Sahota, S.S., et al. Blood 108(12):3953-3955(2006)
Cooper, C.D., et al. Leukemia 20(12):2172-2174(2006)
Guinn, B.A., et al. Biochem. Biophys. Res. Commun. 335(4):1293-1304(2005)
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