|Application ||WB, E|
|Calculated MW||25733 Da|
|Antigen Region||100-127 aa|
|Other Names||Phosphatidylethanolamine-binding protein 4, PEBP-4, hPEBP4, Protein cousin-of-RKIP 1, PEBP4, CORK1|
|Target/Specificity||This PEBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-127 amino acids from the Central region of human PEBP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PEBP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.|
|Tissue Location||Ubiquitously expressed. Highly expressed in tumor cells.|
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Provided below are standard protocols that you may find useful for product applications.
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).
Liu, H., et al. J. Biol. Chem. 285(29):21934-21942(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Garcia, R., et al. EMBO Rep. 10(3):278-284(2009)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
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