|Application ||WB, E|
|Calculated MW||90000 Da|
|Antigen Region||85-114 aa|
|Other Names||Transmembrane protease serine 6, 3421-, Matriptase-2, TMPRSS6|
|Target/Specificity||This TMPRSS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the N-terminal region of human TMPRSS6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMPRSS6 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.|
|Cellular Location||Cell membrane; Single- pass type II membrane protein. Note=The processed, activated two- chains form is released in the extracellular space|
|Tissue Location||Liver specific..|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Altamura, S., et al. Biochem. J. 431(3):363-371(2010)
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
De Falco, L., et al. Hum. Mutat. 31 (5), E1390-E1405 (2010) :
Tanaka, T., et al. Blood 115(1):94-96(2010)
Lee, P. Acta Haematol. 122 (2-3), 87-96 (2009) :
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