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SH3BP4 Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SH3BP4 Antibody(Center) AP19380C
    SH3BP4 Antibody (Center)(Cat. #AP19380c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SH3BP4 antibody detected the SH3BP4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P0V3
Other Accession NP_055336.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107496 Da
Antigen Region 402-429 aa
Additional Information
Gene ID 23677
Other Names SH3 domain-binding protein 4, EH-binding protein 10, Transferrin receptor-trafficking protein, SH3BP4, BOG25, EHB10, TTP
Target/Specificity This SH3BP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-429 amino acids from the Central region of human SH3BP4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSH3BP4 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3BP4
Synonyms BOG25, EHB10, TTP
Function May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Cellular Location Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus
Tissue Location Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
Research Areas
Citations (0)

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This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.


Sebastiani, P., et al. Science (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Thalappilly, S., et al. Proteomics 8(15):3071-3081(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 295.00
$ 99.00
Cat# AP19380C
(40 western blots)
Availability: In Stock
Bulk Size
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