|Application ||WB, E|
|Other Accession||P63014, P63013, Q05437, NP_073207.1|
|Predicted||Chicken, Mouse, Rat|
|Calculated MW||27296 Da|
|Antigen Region||213-242 aa|
|Other Names||Paired mesoderm homeobox protein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRX-1, PRRX1, PMX1|
|Target/Specificity||This PRRX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-242 amino acids from the C-terminal region of human PRRX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||PRRX1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq].
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Hirose, K., et al. Oncogene 27(46):6056-6067(2008)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Jiang, F., et al. Exp. Biol. Med. (Maywood) 233(3):286-296(2008)
Kim, Y.J., et al. Cancer Res. 67(2):546-554(2007)
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