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RECQL5 Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RECQL5 Antibody(Center) AP19444c
    RECQL5 Antibody (Center) (Cat. #AP19444c) western blot analysis in human Uterus tissue lysates (35ug/lane).This demonstrates the RECQL5 antibody detected the RECQL5 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94762
Other Accession NP_001003715.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108858 Da
Antigen Region 662-691 aa
Additional Information
Gene ID 9400
Other Names ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, RecQ5, RecQ protein-like 5, RECQL5, RECQ5
Target/Specificity This RECQL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 662-691 amino acids from the Central region of human RECQL5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRECQL5 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RECQ5
Function Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
Cellular Location Isoform Beta: Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks Isoform Gamma: Cytoplasm.
Tissue Location Ubiquitous.
Citations (0)

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RECQL5 may have an important role in DNA metabolism.


Schwendener, S., et al. J. Biol. Chem. 285(21):15739-15745(2010)
Islam, M.N., et al. Mol. Cell. Biol. 30(10):2460-2472(2010)
Speina, E., et al. Nucleic Acids Res. 38(9):2904-2916(2010)
Aygun, O., et al. J. Biol. Chem. 284(35):23197-23203(2009)
Aygun, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(25):8580-8584(2008)

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Cat# AP19444c
(40 western blots)
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