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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS13 Antibody(Center)   

RGS13 Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RGS13 Antibody(Center) AP19453c
    RGS13 Antibody (Center) (Cat. #AP19453c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RGS13 antibody detected the RGS13 protein (arrow).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O14921
Other Accession NP_658912.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19135 Da
Antigen Region 61-90 aa
Additional Information
Gene ID 6003
Other Names Regulator of G-protein signaling 13, RGS13, RGS13
Target/Specificity This RGS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the Central region of human RGS13.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRGS13 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS13
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha (By similarity).
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.

References

Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Bansal, G., et al. J. Immunol. 181(11):7882-7890(2008)
Han, J.I., et al. J. Leukoc. Biol. 79(6):1357-1368(2006)
Islam, T.C., et al. Leukemia 17(9):1880-1890(2003)

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$ 295.00
$ 99.00
Cat# AP19453c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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