|Application ||WB, E|
|Calculated MW||133067 Da|
|Antigen Region||1134-1162 aa|
|Other Names||ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like type 4, RecQ4, RTS, RecQ protein-like 4, RECQL4, RECQ4|
|Target/Specificity||This RECQL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1162 amino acids from the C-terminal region of human RECQL4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RECQL4 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent ATPase. May modulate chromosome segregation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Ubiquitously expressed, with highest levels in thymus and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq].
Rossi, M.L., et al. DNA Repair (Amst.) 9(7):796-804(2010)
Singh, D.K., et al. Aging Cell 9(3):358-371(2010)
Thangavel, S., et al. Mol. Cell. Biol. 30(6):1382-1396(2010)
Xu, X., et al. EMBO J. 28(19):3005-3014(2009)
Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)
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