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SPIB Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPIB Antibody(C-term) AP19462b
    SPIB Antibody (C-term) (Cat. #AP19462b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SPIB antibody detected the SPIB protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01892
Other Accession Q5EBA3, O35906, NP_003112.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28819 Da
Antigen Region 216-245 aa
Additional Information
Gene ID 6689
Other Names Transcription factor Spi-B, SPIB
Target/Specificity This SPIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the C-terminal region of human SPIB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPIB Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Cellular Location Isoform 1: Nucleus.
Tissue Location Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver
Citations (0)

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SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).


Liu, X., et al. Nat. Genet. 42(8):658-660(2010)
Schmidlin, H., et al. Blood 112(5):1804-1812(2008)
Nagasawa, M., et al. Eur. J. Immunol. 38(9):2389-2400(2008)
Dontje, W., et al. Blood 107(6):2446-2452(2006)
Geng, C.D., et al. J. Biol. Chem. 280(52):43264-43271(2005)

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$ 295.00
$ 99.00
Cat# AP19462b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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