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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   HERC3 Antibody(N-term)   

HERC3 Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HERC3 Antibody(N-term) AP19543a
    HERC3 Antibody (N-term) (Cat. #AP19543a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HERC3 antibody detected the HERC3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15034
Other Accession NP_055421.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 117188 Da
Antigen Region 51-77 aa
Additional Information
Gene ID 8916
Other Names Probable E3 ubiquitin-protein ligase HERC3, 632-, HECT domain and RCC1-like domain-containing protein 3, HERC3, KIAA0032
Target/Specificity This HERC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-77 amino acids from the N-terminal region of human HERC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHERC3 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HERC3
Synonyms KIAA0032
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Cellular Location Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures
Research Areas
Citations (0)

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HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Hochrainer, K., et al. Genomics 85(2):153-164(2005)
Cruz, C., et al. FEBS Lett. 488 (1-2), 74-80 (2001) :
Cruz, C., et al. Cytogenet. Cell Genet. 87 (3-4), 263-264 (1999) :

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Cat# AP19543a
(40 western blots)
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