|Application ||WB, E|
|Calculated MW||33747 Da|
|Antigen Region||263-292 aa|
|Other Names||Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence, KCNK6, TOSS, TWIK2|
|Target/Specificity||This KCNK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human KCNK6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNK6 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus Lowest expression detected in brain|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq].
Sebastiani, P., et al. Am. J. Hematol. 85(1):29-35(2010)
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)
Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)
Mhatre, A.N., et al. J. Neurosci. Res. 75(1):25-31(2004)
Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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