|Application ||WB, E|
|Calculated MW||30420 Da|
|Antigen Region||30-59 aa|
|Other Names||Fibroblast growth factor 8, FGF-8, Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8, Fgf8, Aigf|
|Target/Specificity||This Mouse Fgf8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of mouse Fgf8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Fgf8 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus- induced murine mammary tumorigenesis (PubMed:7884899).|
|Tissue Location||Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos|
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Provided below are standard protocols that you may find useful for product applications.
Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis.
Yu, S., et al. Dev. Biol. 347(1):92-108(2010)
Toyoda, R., et al. Development 137(20):3439-3448(2010)
Leung, A.W., et al. Dev. Dyn. 239(9):2319-2329(2010)
Mao, J., et al. Development 137(18):3079-3088(2010)
Mitsiadis, T.A., et al. Development 137(18):3025-3035(2010)
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