|Application ||WB, E|
|Other Accession||NP_001180309.1, NP_705613.1, NP_705616.2|
|Calculated MW||74810 Da|
|Antigen Region||87-116 aa|
|Other Names||Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE|
|Target/Specificity||This IL17RE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human IL17RE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL17RE Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Secreted.|
|Tissue Location||Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that shares limited similarity with the interleukin-17 receptor. The function of the encoded protein has not yet been determined. Alternatively spliced transcript variants have been described.
Eid, N.A., et al. Malar. J. 9, 119 (2010) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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