|Application ||WB, E|
|Calculated MW||25454 Da|
|Antigen Region||63-90 aa|
|Other Names||Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1|
|Target/Specificity||This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||ASCL1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASH1, BHLHA46, HASH1|
|Function||Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
Phi, J.H., et al. J Neurosurg Pediatr 5(6):608-614(2010)
McGaughey, D.M., et al. Genomics 95(6):363-369(2010)
Li, F., et al. Zhongguo Fei Ai Za Zhi 13(4):317-321(2010)
Deng, H., et al. Biochem. Biophys. Res. Commun. 392(4):548-550(2010)
Improgo, M.R., et al. Mol. Cancer Res. 8(2):194-203(2010)
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