|Application ||WB, E|
|Calculated MW||100124 Da|
|Antigen Region||814-843 aa|
|Other Names||Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, E-NPP 3, Phosphodiesterase I beta, PD-Ibeta, Phosphodiesterase I/nucleotide pyrophosphatase 3, CD203c, Alkaline phosphodiesterase I, Nucleotide pyrophosphatase, NPPase, ENPP3, PDNP3|
|Target/Specificity||This ENPP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814-843 amino acids from the C-terminal region of human ENPP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENPP3 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.|
|Cellular Location||Membrane; Single-pass type II membrane protein. Secreted Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells|
|Tissue Location||Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells and their progenitors.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ono, E., et al. J. Allergy Clin. Immunol. 125(2):483-489(2010)
Wolanczyk-Medrala, A., et al. Ann Agric Environ Med 16(2):301-304(2009)
Chirumbolo, S., et al. Inflamm. Res. 58(11):755-764(2009)
Ocmant, A., et al. J. Immunol. Methods 320 (1-2), 40-48 (2007) :
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