|Application ||WB, E|
|Other Accession||P70193, NP_056356.2|
|Calculated MW||119113 Da|
|Antigen Region||801-829 aa|
|Other Names||Leucine-rich repeats and immunoglobulin-like domains protein 1, LIG-1, LRIG1, LIG1|
|Target/Specificity||This LRIG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 801-829 amino acids from the C-terminal region of human LRIG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LRIG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
LRIG1 act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ye, F., et al. J. Neurooncol. 94(2):183-194(2009)
Ljuslinder, I., et al. Breast Cancer Res. 11 (3), 403 (2009) :
Miller, J.K., et al. Cancer Res. 68(20):8286-8294(2008)
Stutz, M.A., et al. Oncogene 27(43):5741-5752(2008)
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