|Application ||WB, E|
|Calculated MW||65331 Da|
|Antigen Region||383-412 aa|
|Other Names||Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, MAC2BP, Mac-2 BP, Tumor-associated antigen 90K, LGALS3BP, M2BP|
|Target/Specificity||This LGALS3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the Central region of human LGALS3BP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LGALS3BP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.|
|Cellular Location||Secreted. Secreted, extracellular space, extracellular matrix|
|Tissue Location||Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Srirajaskanthan, R., et al. Mol. Cell Proteomics 9(4):656-666(2010)
Zambelli, D., et al. Int. J. Cancer 126(1):41-52(2010)
Lee, J.H., et al. Pathology 41(3):229-233(2009)
Kim, S.J., et al. Acta Haematol. 120(4):211-216(2008)
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