|Application ||WB, E|
|Other Accession||P09174, P18545, P04972, P61250, P61249, P22571, NP_006196.1|
|Predicted||Bovine, Rat, Human|
|Calculated MW||9074 Da|
|Antigen Region||4-33 aa|
|Other Names||Retinal cone rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma, PDE6H|
|Target/Specificity||This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE6H Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Piri, N., et al. Ophthalmology 112(1):159-166(2005)
Kajimura, N., et al. J. Struct. Biol. 139(1):27-38(2002)
Shimizu-Matsumoto, A., et al. Genomics 32(1):121-124(1996)
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