|Application ||WB, E|
|Other Accession||Q148H8, NP_542785.1|
|Calculated MW||55877 Da|
|Antigen Region||313-342 aa|
|Other Names||Keratin, type II cytoskeletal 72, Cytokeratin-72, CK-72, Keratin-72, K72, Type II inner root sheath-specific keratin-K6irs2, Type-II keratin Kb35, KRT72, K6IRS2, KB35, KRT6, KRT6IRS2|
|Target/Specificity||This KRT72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-342 amino acids from the Central region of human KRT72.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KRT72 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||K6IRS2, KB35, KRT6, KRT6IRS2|
|Function||Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).|
|Tissue Location||Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.
Bertheau, P., et al. PLoS Med. 4 (3), E90 (2007) :
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Langbein, L., et al. J. Invest. Dermatol. 120(4):512-522(2003)
Porter, R.M., et al. Br. J. Dermatol. 145(4):558-568(2001)
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