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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GGT1 Antibody (N-term)   

GGT1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GGT1 Antibody (N-term) AP19816a
    GGT1 Antibody (N-term) (Cat. #AP19816a) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the GGT1 antibody detected the GGT1 protein (arrow).
  • WB - GGT1 Antibody (N-term) AP19816a
    GGT1 Antibody (N-term) (Cat. #AP19816a) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the GGT1 antibody detected the GGT1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19440
Other Accession A6NGU5, P36268, P07314, P20735, Q60928, NP_038347.2
Reactivity Human, Mouse
Predicted Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61410 Da
Antigen Region 124-152 aa
Additional Information
Gene ID 2678
Other Names Gamma-glutamyltranspeptidase 1, GGT 1, Gamma-glutamyltransferase 1, Glutathione hydrolase 1, Leukotriene-C4 hydrolase, CD224, Gamma-glutamyltranspeptidase 1 heavy chain, Gamma-glutamyltranspeptidase 1 light chain, GGT1, GGT
Target/Specificity This GGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human GGT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGGT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GGT1
Synonyms GGT
Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein
Research Areas
Citations (0)

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The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified.


Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Ikeda, M., et al. Scand. J. Clin. Lab. Invest. 70(3):171-179(2010)
Fujita, M., et al. Exp. Biol. Med. (Maywood) 235(3):335-341(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Diergaarde, B., et al. Pancreatology 10 (2-3), 194-200 (2010) :

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$ 295.00
$ 99.00
Cat# AP19816a
(40 western blots)
Availability: In Stock
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