|Application ||WB, IHC-P, FC, E|
|Other Accession||P17325, P56432, P05627, P18870, O77627|
|Predicted||Bovine, Chicken, Mouse, Pig, Rat|
|Calculated MW||35676 Da|
|Antigen Region||222-251 aa|
|Other Names||Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN|
|Target/Specificity||This JUN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human JUN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JUN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).|
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Provided below are standard protocols that you may find useful for product applications.
JUN is the putative transforming gene of avian sarcoma virus 17. JUN is a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Song, J.Y., et al. J. Biol. Chem. 285(12):9067-9076(2010)
Jiao, X., et al. J. Biol. Chem. 285(11):8218-8226(2010)
Carrillo, R.J., et al. J. Mol. Biol. 396(2):431-440(2010)
Maritzen, T., et al. J. Biol. Chem. 285(6):4074-4086(2010)
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