|Application ||WB, E|
|Other Accession||P02103, NP_005321.1|
|Calculated MW||16203 Da|
|Antigen Region||55-83 aa|
|Other Names||Hemoglobin subunit epsilon, Epsilon-globin, Hemoglobin epsilon chain, HBE1, HBE|
|Target/Specificity||This HBE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the Central region of human HBE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HBE1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.|
|Tissue Location||Red blood cells.|
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Provided below are standard protocols that you may find useful for product applications.
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'
Nuinoon, M., et al. Hum. Genet. (2009) In press :
Tachavanich, K., et al. Southeast Asian J. Trop. Med. Public Health 40(2):306-316(2009)
Naka, I., et al. Biochem. Genet. 46 (11-12), 708-711 (2008) :
Winichagoon, P., et al. Transl Res 152(4):178-184(2008)
Das, B., et al. Ann. Hum. Biol. 35(4):422-431(2008)
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