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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KIRREL Antibody(C-term)   

KIRREL Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KIRREL Antibody(C-term) AP19861b
    KIRREL Antibody (C-term) (Cat. #AP19861b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the KIRREL antibody detected the KIRREL protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96J84
Other Accession Q6X936, Q80W68, NP_060710.3
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 83536 Da
Antigen Region 505-534 aa
Additional Information
Gene ID 55243
Other Names Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1
Target/Specificity This KIRREL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human KIRREL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKIRREL Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIRREL1, NEPH1
Function Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm
Tissue Location Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli
Research Areas
Citations (0)

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NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).


Machuca, E., et al. J. Am. Soc. Nephrol. 21(7):1209-1217(2010)
Wagner, M.C., et al. J. Biol. Chem. 283(51):35579-35589(2008)
Hartleben, B., et al. J. Biol. Chem. 283(34):23033-23038(2008)
Harita, Y., et al. J. Biol. Chem. 283(14):9177-9186(2008)
Ihalmo, P., et al. Diabetologia 51(1):86-90(2008)

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$ 295.00
$ 99.00
Cat# AP19861b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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