|Application ||WB, E|
|Other Accession||Q6X936, Q80W68, NP_060710.3|
|Calculated MW||83536 Da|
|Antigen Region||505-534 aa|
|Other Names||Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1|
|Target/Specificity||This KIRREL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human KIRREL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIRREL Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm|
|Tissue Location||Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli|
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Provided below are standard protocols that you may find useful for product applications.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).
Machuca, E., et al. J. Am. Soc. Nephrol. 21(7):1209-1217(2010)
Wagner, M.C., et al. J. Biol. Chem. 283(51):35579-35589(2008)
Hartleben, B., et al. J. Biol. Chem. 283(34):23033-23038(2008)
Harita, Y., et al. J. Biol. Chem. 283(14):9177-9186(2008)
Ihalmo, P., et al. Diabetologia 51(1):86-90(2008)
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