|Application ||WB, E|
|Other Accession||Q8BU31, Q08DI5, P61227, P61226, P61225, Q06AU2, Q80ZJ1, P10114, NP_067006.3|
|Predicted||Pig, Rat, Bovine|
|Calculated MW||20745 Da|
|Antigen Region||14-42 aa|
|Other Names||Ras-related protein Rap-2c, RAP2C|
|Target/Specificity||This RAP2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human RAP2C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAP2C Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.|
|Cellular Location||Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
Guo, Z., et al. Mol. Biol. Rep. 34(3):137-144(2007)
Paganini, S., et al. Biochimie 88 (3-4), 285-295 (2006) :
Ross, M.T., et al. Nature 434(7031):325-337(2005)
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