ELOVL3 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9HB03 |
Other Accession | NP_689523.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 31500 Da |
Antigen Region | 241-270 aa |
Gene ID | 83401 |
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Other Names | Elongation of very long chain fatty acids protein 3, 3-keto acyl-CoA synthase ELOVL3, Cold-inducible glycoprotein of 30 kDa, ELOVL fatty acid elongase 3, ELOVL FA elongase 3, Very-long-chain 3-oxoacyl-CoA synthase 3, ELOVL3, CIG30 |
Target/Specificity | This ELOVL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-270 amino acids from the C-terminal region of human ELOVL3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ELOVL3 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ELOVL3 {ECO:0000255|HAMAP-Rule:MF_03203} |
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Synonyms | CIG30 |
Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03203} |
Tissue Location | Testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ELOVL3 plays a role in fatty acid chain elongation and formation of neutral lipids required for skin barrier function (Westerberg et al., 2004 [PubMed 14581464]).
References
Kobayashi, T., et al. FEBS Lett. 581(17):3157-3163(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Westerberg, R., et al. J. Biol. Chem. 279(7):5621-5629(2004)
Monne, M., et al. Eur. J. Biochem. 263(1):264-269(1999)
Lehner, R., et al. Prog. Lipid Res. 35(2):169-201(1996)
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