|Application ||FC, WB, E|
|Other Accession||Q6IE59, Q14B24, NP_999875.1|
|Calculated MW||30334 Da|
|Antigen Region||225-254 aa|
|Other Names||Serine protease 57, 3421-, Serine protease 1-like protein 1, PRSS57, PRSSL1|
|Target/Specificity||This PRSSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-254 amino acids from the C-terminal region of human PRSSL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRSSL1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428).|
|Cellular Location||Cytoplasmic granule lumen Secreted. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils.|
|Tissue Location||Detected in peripheral blood neutrophil granulocytes, but not in other types of leukocytes. Detected in neutrophils and neutrophil precursors in bone marrow (at protein level) (PubMed:22474388, PubMed:23904161). Detected in myeloblasts and promyelocytes in bone marrow (PubMed:23904161)|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein is unknown.
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Polikoff, D., et al. Cytogenet. Cell Genet. 79 (1-2), 147-148 (1997) :
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