|Application ||WB, E|
|Calculated MW||37490 Da|
|Antigen Region||127-156 aa|
|Other Names||Cysteine and histidine-rich domain-containing protein 1, CHORD domain-containing protein 1, CHORD-containing protein 1, CHP-1, Protein morgana, CHORDC1, CHP1|
|Target/Specificity||This CHORDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human CHORDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHORDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.|
|Tissue Location||Underexpressed in many breast and lung cancers.|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1 (By similarity).
Gano, J.J., et al. Mol. Cell Proteomics 9(2):255-270(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wu, J., et al. FEBS Lett. 579(2):421-426(2005)
Brancaccio, M., et al. FEBS Lett. 551 (1-3), 47-52 (2003) :
Shirasu, K., et al. Cell 99(4):355-366(1999)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.